Preheat oven to 350º
Sift first 6 ingredients into a large bowl.
Cut in shortening with pastry blender.
Add buttermilk and vanilla, beat for two minutes on low speed with a hand mixer or stand mixer or 200 strokes by hand.
Add eggs and beat again for two minutes.
Bake in a greased loaf pan 9x5x3 inches for 50 to 60 minutes.